![]() It is known that COX is the key enzyme in the conversion of arachidonic acid toprostaglandin E 2 (PGE 2), the precursor of a diverse family ofbioactive lipid mediators including prostaglandins, thromboxane, and prostacyclin.It exists in two isoforms, namely COX-1 and COX-2. Despite thecharacterization of a variety of key participants, the mediators and mechanismsinvolved in the pathogenesis of IPF and SSc have yet to be fully defined, whichmight explain the limited number of therapeutic approaches, with little impact onlong-term survival.(,) Lung remodeling is a common end-stage sequela of idiopathic pulmonary fibrosis (IPF)and systemic sclerosis (SSc), resulting in disruption of lung architecture, leadingto progressive respiratory failure.(1-)Histologically, the remodeling process is characterized by diffuse chronicinterstitial inflammation and increased fibroblast proliferation, as well as byincreased extracellular matrix synthesis and collagen deposition.(,)Therefore, modulation of inflammation, fibroblast proliferation, and collagensynthesis by effector mediators in IPF and SSc is very important. Keywords: Scleroderma, systemic Idiopathic pulmonary fibrosis Inflammation Survival rate Introduction However, prospectiverandomized clinical trials are needed in order to confirm that. Our findings suggest that strategies aimed at preventing low COX-1 synthesiswill have a greater impact on SSc, whereas those aimed at preventing highCOX-2 synthesis will have a greater impact on IPF. Multivariate analysis based on the Cox regression modelshowed that the factors associated with a low risk of death were youngerage, high DLCO/alveolar volume, IPF, and high COX-1 expression in alveolarsepta, whereas those associated with a high risk of death were advanced age,low DLCO/alveolar volume, SSc (with NSIP), and low COX-1 expression inalveolar septa. Nodifference was found between IPF-UIP and SSc-NSIP tissue regarding COX-1 andCOX-2 expression. ![]() The expression of COX-1 and COX-2 in alveolar septa was significantly higherin IPF-UIP and SSc-NSIP lung tissue than in the control tissue. ![]() We thencorrelated that expression with pulmonary function test results andevaluated its impact on patient survival. We usedimmunohistochemistry and histomorphometry to evaluate the expression ofCOX-1 and COX-2 in alveolar septa, vessels, and bronchioles. The histological patternsincluded fibrotic nonspecific interstitial pneumonia (NSIP) in SSc patientsand usual interstitial pneumonia (UIP) in IPF patients. We examined open lung biopsy specimens from 24 SSc patients and 30 IPFpatients, using normal lung tissue as a control. To study the expression of COX-1 and COX-2 in the remodeled lung in systemicsclerosis (SSc) and idiopathic pulmonary fibrosis (IPF) patients,correlating that expression with patient survival. ![]() #CBTRICKS MODULACAO POSITIVA NO VR MANUALS#I have added a area where CB and Ham radio electronics technicalinformation on DVD's, ranging from radio's manuals and test equipmentmanuals.Disclaimer:Radio modificationsshown here are provided for properly licensed operators only!The user is solely responsible for making sure that any modificationsmade to the radio unit must meet all Federal and State Regulations orthe Country of use! Liability of damages to any equipment is the soleresponsibility of the user! Downloading, viewing, or using any informationprovided on these pages automatically accepts the user to the termsof this agreement! Modifications are provided for information purposesonly!AllTrademarks, Logos, and Brand Names are the the property of their respectiveowners.This information is not provided by, or affiliated in any way with anyradio or antenna Manufacturers.This article has been cited by other articles in PMC. ![]() #CBTRICKS MODULACAO POSITIVA NO VR FREE#To date the site has been primarilysponsored by myself (Bennie Bolin) and donations from some of the greatRadio enthusiasts out there.It is my intent that CBTricks shall remain both free to use and freeof commercial content.In an effort tooffset the growing costs of providing this service I've made a toughdecision. This is a personal, private venture with no commercialcontent.The site is maintained as a commercial free zone and is requiressignificant resources to stay online. AgainThank You for the SupportCBTricksis dedicated to the preservation, conservation and disseminationof current and vintage CB and Ham radio electronics technicalinformation. ![]()
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